Pain at the back of the palate near the mouth of the throat can be considered to be related to diseases of the pharyngeal isthmus, such as pharyngeal foreign body, pharyngitis or pharyngeal mucosal ulcers. 1. Pharyngeal foreign body: accidentally swallowing fish spines, meat and bones, or leaving gauze or hemostatic ball in the nasopharynx during medical surgery, and not removing them in time to form a foreign body, which can cause foreign body sensation, discomfort or pain in the pharynx. 2. Pharyngitis: Bacterial or viral infection or dryness, smoke and other environmental factors can cause acute pharyngitis, patients have pharyngeal dryness, obvious pharyngeal pain, and swallowing is particularly heavy, oropharyngeal mucous membrane has congestion and swelling. 3. Pharyngeal mucosal ulcers: If the resistance drops, lack of vitamins and infections, mucosal ulcers can occur in the uvula, soft palate, tongue surface, etc., and the symptoms of sore throat and pharyngeal foreign body sensation occur. When such symptoms occur, it is recommended to actively seek medical treatment to clarify the causes of pain and treat the cause and symptoms.