Cerebral leukomalacia is an imaging diagnosis of diffuse cerebral ischemia on CT or MRI films, resulting in demyelinating changes in the white matter of the brain. It is mainly seen as a punctiform or parietal demyelinating change in the anterior and posterior horn of the brain in the white matter distribution area. The age of onset of the disease is mainly in the elderly, such as a history of hypertension, diabetes mellitus and other small vascular lesions of the brain. There are also cases of middle-aged onset, which may be related to genetic factors. The main symptom is the loss of brain function, such as chronic progressive memory loss, unresponsiveness, dizziness, drowsiness and other signs of dementia, and some patients may have a combination of hallucinations, hallucinations, mania, uncontrolled behavior and other psychiatric symptoms.