For patients with heart and kidney failure, the following symptoms will eventually appear: 1. Dysfunction of the digestive system, there will be due to long-term inability to eat, resulting in digestive and absorption dysfunction, the patient will experience extreme emaciation and nausea, anorexia, anorexia, vomiting, abdominal distension and so on.2. There will be obvious cardiac arrhythmia, tachycardia, palpitations, chest tightness, shortness of breath. Sometimes patients may have lying down inability, sitting breathing, coughing, coughing up sputum, coughing up pink foamy sputum, nocturnal paroxysmal dyspnea and so on.3. For patients with predominantly renal insufficiency, accompanied by cardiac failure, clinical signs and symptoms such as swelling of limbs, peripheral edema, oliguria, anuria, tea-colored urine, soy sauce-colored urine and other clinical symptoms and manifestations will also be seen in the late stage.