Middle ear effusion after radiotherapy for nasopharyngeal cancer belongs to the complications of radiotherapy for nasopharyngeal cancer, which is clinically called secretory otitis media. Its treatment modes include medication, fluid extraction and surgery. 1. Drug treatment: due to congestion and edema of tympanic membrane caused by radiation damage, it is recommended to take antibiotics, such as macrolides and cephalosporins, and use corticosteroid aerosol locally in the nasal cavity under the guidance of doctor. 2. Fluid extraction treatment: when drug treatment is ineffective, fluid extraction treatment is feasible, such as tympanic membrane puncture fluid extraction. 3. Surgical treatment: if the patient’s medication and fluid extraction treatment are ineffective, surgical treatment can be chosen, such as tympanotomy tube placement. It is recommended that patients actively seek medical treatment to avoid delays.