Two calf pain can be caused by the following reasons: first, lumbar spine disease, when the lumbar disc herniation or lumbar spinal stenosis seriously compressed the nerve roots on both sides, there can be pain on both sides of the calf, at the same time can be accompanied by hip discomfort and foot back, plantar discomfort symptoms, this time to check the lumbar spine CT, magnetic resonance to diagnose. Second, cold, when sleeping with cold, can also have two calf pain symptoms, often due to inflammation of the calf fascia, then we should get out of the cold environment, early attention to warmth and physical therapy. Thirdly, lower limb vein thrombosis, if there is vein thrombosis in bilateral calves, there can also be pain in both calves, which should be diagnosed by early examination of vascular ultrasound. Fourth, varicose veins, varicose veins of the lower limbs can also lead to calf pain, often accompanied by swelling and leg soreness, then we should take vascular ultrasound examination of the lower limbs and physical examination to diagnose.