Creatinine 130μmol / L, if the physiological factors caused by the elevation of the general does not need treatment, if the pathological factors caused by the elevation of the need to identify the cause of compliance with the doctor’s instructions in a timely and symptomatic treatment. The normal value of creatinine in China is 53～106μmol/L for men and 44～97μmol/L for women, with a slight difference in the reference range of each hospital. 1. Physiological factors: when consuming too much meat, or recent increase in exercise, the body’s protein metabolism increases, it may be manifested in the blood creatinine increase, remove the causative factors can be adjusted to return to normal, generally do not need treatment. 2. Pathological factors: when kidney diseases such as glomerulonephritis, urinary tract infections, diabetic nephropathy, hypertensive kidney damage, etc., the efficiency of creatinine removal by kidneys will be reduced, and creatinine value will increase. It is necessary to give allopathic and symptomatic treatments as prescribed by doctor to slow down the rate of kidney progression after clarifying the cause of the disease. When the creatinine is 130μmol/L, it is recommended to consult the hospital in time, follow the doctor’s instructions to improve the examination, clarify the cause of the disease and then give the symptomatic treatment, so as to avoid delaying the condition.