Surgical methods for acute duodenal perforation include conservative treatment and perforation repair. 1. Conservative treatment: mainly applicable to mild symptoms, limited peritonitis, or poor systemic conditions, intolerance of surgical treatment. The method mainly involves continuous gastrointestinal decompression, rehydration to maintain water, electrolyte and acid-base balance, in addition to strengthening the nutritional support; at the same time, omeprazole injection is given to inhibit acid to protect the gastric mucosa, and systemic antibiotics are applied to fight infection, such as cefprozil and ornidazole and other comprehensive treatments. 2. Perforation repair: mainly for perforation within 8 hours, or more than 8 hours but the abdominal cavity is not seriously contaminated. Surgical methods mainly under general anesthesia for laparoscopic duodenal perforation repair. Acute duodenal perforation surgery, need to choose the treatment method according to the specific condition, it is recommended that the patient once found, as soon as possible to follow the doctor’s instructions, to avoid delaying the condition.