The common causes of high leukocyte platelet hypoplasia are: i. After immune thrombocytopenic purpura patients take hormone therapy, it will cause a significant increase in the number of leukocytes in peripheral blood. But before the number of platelets is restored, the number of platelets is reduced, and the situation of high leukocyte platelet hypoplasia will occur. Second, acute bacterial infection, bacterial infection will cause an increase in the number of white blood cells, but some bacterial infections or the application of certain drugs will cause the number of platelets immune reduction, there will be a high white blood cells and platelet reduction. Third, in patients with acute leukemia, as leukemia cells proliferate in the bone marrow and are released into the peripheral blood, the normal hematopoietic function is damaged, so the number of leukocytes in the peripheral blood is significantly higher, while the number of platelets is reduced. Therefore, there are various reasons for high white blood cells and low platelets, which need to be analyzed for specific conditions.