Bladder cancer combined with lymph node metastasis can be treated, and it needs to choose surgery, targeting, immunotherapy and chemotherapy according to the situation. Bladder cancer is the fourth most common malignant tumor among men and the eighth most common malignant tumor among women, with clinical manifestations of intermittent painless hematuria, irritation of urinary tract and urinary difficulty, and local lymph node metastasis, peripelvic infiltration and distant metastasis can appear in the middle and late stages, which will lead to corresponding clinical symptoms. Bladder cancer combined with lymph node metastasis suggests that it has already spread and metastasized, which suggests that the prognosis is relatively poor, but it can be treated by comprehensive therapy such as surgical resection combined with lymph node dissection, radiotherapy, chemotherapy and targeted therapy, which can improve the quality of patients’ life and prolong their survival time. If only local lymph node metastasis has occurred, radical cystectomy combined with peripheral lymph node dissection can be accepted, and chemotherapy or immunotherapy can be given after surgery according to the situation. If distant metastasis has occurred, etc., radiotherapy and immunotherapy can be given according to the situation, such as gemcitabine, paclitaxel, cisplatin and other drugs. In addition, if there are symptoms such as difficulty in urination, serious hematuria, pain, etc., bladder irrigation, interventional embolization, pain relief treatment, etc. can be given according to the situation to improve the quality of life of patients. Bladder cancer patients should pay attention to it. If bladder tumor is suspected or diagnosed, it is recommended to go to regular hospitals for comprehensive assessment of the condition, follow the doctor’s instructions to cooperate with the treatment, and choose the appropriate treatment plan to avoid delaying the condition.