In advanced stages of chondrosarcoma, NSAIDs, weak opioids, and strong opioids are chosen for pain relief depending on the severity of the pain. In advanced chondrosarcoma, if the pain is mild, you can first choose non-steroidal anti-inflammatory and analgesic drugs for pain relief, such as ibuprofen, nimesulide, celecoxib, and so on. If the pain is moderate, you can choose weak opioids such as codeine hydrochloride, tramadol hydrochloride and so on. In case of severe pain, you can opt for strong opioids like morphine, pethidine, etc. Non-steroidal pain medications have weak pain relief and non-addictive characteristics, while opioids have good pain relief but may be addictive. Combination of drugs as well as alternation of drugs are recommended for pain relief, which can effectively improve the pain relief effect and reduce drug dependence. When patients with advanced chondrosarcoma choose painkillers for treatment, it is recommended to go to the hospital for medical treatment, and use drugs under the guidance of doctors in a reasonable and regular manner, do not use drugs blindly.