Uremia is more difficult to cure in the early stage and is an irreversible disease that can only be cured by kidney transplantation. Chronic renal failure progresses to end-stage renal disease, which is called uremia. Clinical manifestations are water, electrolyte and acid-base balance imbalance and systemic symptoms. If renal failure enters into uremia stage, the progression of the disease should be controlled by treatment in time. This includes limiting the protein diet and reducing the intake of nitrogenous substances; oral sodium bicarbonate to correct metabolic acidosis; and timely anti-infective treatment, such as cefuroxime, for those with concurrent infections. In addition, renal replacement therapy can be prepared, including hemodialysis, peritoneal dialysis and kidney transplantation. Successful kidney transplantation can restore normal kidney function. Uremia is a refractory disease, therefore, in the early stage of chronic kidney disease, it should be treated in time to control the progression of the disease to avoid entering into the uremic stage, the specific treatment can be consulted with the professional physician’s opinion.