Pregnant women with toothache that prevents them from sleeping at night should be treated according to the specific disease, such as apical periapical inflammation, endodontitis, wisdom tooth pericoronitis, etc., which is usually treated locally or with oral medication. 1. Periapical inflammation: this is a kind of inflammatory disease that occurs in the tissues around the root of the tooth, you can use hydrogen peroxide solution to rinse, and then the local incision for drainage, and finally the local use of iodine preparation, anti-bacterial and anti-inflammatory, and the usual use of chlorhexidine gargle. If the symptoms are more serious, you also need to take oral medication at the same time, such as amoxicillin, metronidazole and so on. 2. Pulpitis: Pulpitis is an inflammation caused by pathogenic bacteria infecting the pulp of the tooth through the tooth defect, which can reduce the pain by opening the pulp and draining, and at the same time use antibacterial and anti-inflammatory drugs, such as metronidazole, tinidazole, and usually use chlorhexidine gargle. For particularly serious cases, root canal treatment is needed. 3. Wisdom teeth pericoronitis: This is a purulent inflammatory disease that occurs in the soft tissues around the crown of the tooth, you can use potassium permanganate solution or hydrogen peroxide solution to rinse in the blind pocket, to promote the discharge of pus, to remove the food debris and so on so that you can also alleviate the toothache, for the serious ones can be taken orally at the same time, such as cefixime, metronidazole and other medication. When the birth can be elective surgery to remove the wisdom teeth. The use of medication during pregnancy is very cautious, including some auxiliary treatment methods, but also need to be used correctly under the strict guidance of the doctor, pay attention to the metronidazole in the first three months of pregnancy is prohibited, can not just mess with the drug. When the symptoms of the disease should be as soon as possible to seek medical attention, do not delay the disease.