Lymphoma is a hematologic disease and one of the common malignant tumors of the head and neck. Lymphoma of head and neck often affects lymph nodes of head and neck, nasal cavity, oral cavity, pharynx, paranasal sinus, orbit, skull base and soft tissues of face, etc. It may present with various clinical manifestations such as headache, nasal congestion, pus and blood snot, nasal swelling, enlarged and ulcerated tonsils, hoarseness, protruding eyes, diplopia, facial swelling, neck mass, fever, emaciation and night sweats. Lymphoma of the head and neck involves complex structures and various pathological types, and scientific and standardized diagnosis and treatment require the joint participation of multiple disciplines. Beijing Tongren Hospital has formed a comprehensive diagnosis and treatment team for head and neck lymphoma with hematology, otorhinolaryngology, head and neck surgery, ocular oncology, stomatology, pathology, and imaging center as the main subjects to provide first-class treatment services for head and neck lymphoma patients. Among them, minimally invasive biopsy surgery and local examination and treatment in otorhinolaryngology-head and neck surgery, ocular oncology and stomatology, immunohistochemistry and molecular pathology diagnosis in pathology, high-resolution imaging evaluation in imaging center, and system examination, comprehensive decision making, combined chemotherapy, immunotherapy, targeted therapy, autologous/allogeneic hematopoietic stem cell transplantation, treatment of complications and comorbidities, follow-up evaluation, and rehabilitation guidance in hematology department are all the most important services. It is an important part of the scientific and standardized treatment process of head and neck lymphoma, and is also a key factor to obtain the best curative effect. After scientific and standardized diagnosis and treatment by our comprehensive diagnosis and treatment team, the efficacy and prognosis of head and neck lymphoma patients have significantly improved, and more and more patients are surviving for a long time or even cured.