High creatine kinase is not usually fatal, but in a small percentage of patients it can be caused by the progression of the primary disease. Creatine kinase is mainly found in skeletal muscle and cardiac muscle. Abnormalities in creatine kinase can be used to diagnose and evaluate skeletal muscle and cardiac muscle-related diseases, such as rhabdomyolysis, myocarditis, and myocardial infarction. Elevated levels of creatine kinase can reflect the severity of the disease to a certain extent, but mild elevation of this index can also occur in some physiological conditions, such as after strenuous activities, but after rest, this index can be completely restored to the normal range, and there will be no obvious abnormalities in the body. As for the elevation of creatine kinase caused by the above mentioned pathologic diseases, the mild elevation usually indicates that the disease is still under control, and after timely and effective treatment, the index will gradually return to normal as the disease recovers, and will not be fatal. However, if the disease cannot be effectively controlled, creatine kinase may increase as the disease progresses, and the condition may deteriorate or even become fatal. In conclusion, whether or not high creatine kinase is fatal varies from person to person, and is mainly related to the primary disease; if you find abnormal creatine kinase, you must consult a doctor in time, and don’t delay your condition, so as not to cause serious consequences.