Letrozole tablets may cause impaired fertility in men, but this finding has not been confirmed in the authoritative literature; in addition, the drug may cause adverse reactions such as urinary tract infections, but this symptom is not gender-specific. Letrozole tablets are mainly used for the treatment of postmenopausal estrogen or progesterone receptor-positive early-stage breast cancer, men usually do not need to take the drug, if it is confirmed that men have the above disease and need to take the drug treatment, it may lead to male fertility decline. In addition, taking the drug in men with breast cancer may also lead to urinary tract infection, pain, blood cell reduction, dyslipidemia, decreased appetite, depression and anxiety, headache and other adverse reactions, but there is no gender difference in such adverse reactions, and prompt medical consultation is recommended for the occurrence of such adverse reactions. Drug allergy, premenopause, pregnancy, lactation, children, adolescents and other prohibited to take the drug. Letrozole needs to be used under the supervision of a clinician.