Cough, headache, chest tightness generally refers to cough-induced headache and chest tightness, which may be caused by a variety of reasons, such as upper respiratory tract infections, chronic bronchitis and so on. Treatment can be relieved by taking drugs, need to be specifically analyzed. 1. Upper respiratory tract infection: If caused by bacterial infection, it can be treated with antibiotics such as amoxicillin and cefixime. If caused by viral infection, generally no antiviral treatment. If the dry cough is severe, dextromethorphan and other cough suppressants can be used; if the cough is accompanied by sputum, aminoglutethimide, bromhexine and other sputum removing drugs can be used. 2. Chronic bronchitis: In acute attacks of chronic bronchitis, there may be coughing, sputum, wheezing, accompanied by headache caused by hypoxemia. First of all, patients need to control the infection, can use levofloxacin, amoxicillin and other antibiotics; secondly, can be given to aminoglutethimide, bromhexine and other expectorant. If wheezing symptoms are severe, aminophylline can be given to improve symptoms. Cough, headache, chest tightness can also be caused by other diseases, if the symptoms are not relieved or aggravated, it is recommended to go to the hospital for examination in a timely manner, and standardized treatment under the guidance of the doctor.