Hand, foot and mouth disease fever does not go down, the specific treatment is as follows: 1, the child meets the application of antipyretic drug indications, you can take oral antipyretic drugs, such as acetaminophen or ibuprofen oral solution. 2, after taking the medicine within one hour, must grasp with the physical cooling to reduce the fever. Physical cooling can choose to repeatedly drink more water, drink warm water, you can use antipyretic patches on the neck, forehead, limbs and other parts of the body, you can also use warm water repeatedly and continuously on the child’s limbs, neck, armpits, groin and other parts of the blood vessels to wipe, if the child does not have chills, cold phenomenon, you can also give the child a bath, after the above oral medication combined with physical cooling can be reduced fever after. The fever can subside after oral medication combined with physical cooling. If the fever persists even after medication and physical cooling, the child should be taken to the hospital for intramuscular injection or intravenous infusion of antipyretic drugs to reduce fever.