Cardioplegia i.e. propafenone, propafenone and amiodarone are suitable for patients with different types of frequent premature beats and are not comparable in terms of superiority or inferiority. Amiodarone is more suitable for patients with frequent premature beats accompanied by poor cardiac function and fast heart rate, which can lower the heart rate, but will lead to prolongation of the QT interval on the electrocardiogram, and may even be detrimental to the health of the thyroid gland, which may lead to thyroid dysfunction, and is contraindicated in people with severe hypotension. Propafenone, on the other hand, is more suitable for frequent premature beats with good cardiac function, post-myocarditis, coronary artery disease, while it is generally not used in patients with decreased cardiac function, not for bradycardia, severe conduction block. It is contraindicated in the presence of obstructive lung disease, sick sinus node syndrome, and significant electrolyte disturbances. It should be noted that both propafenone and amiodarone need to be used under the supervision of a doctor, not on their own. In the event of frequent premature beats, it is recommended to seek medical attention, follow the doctor’s instructions for examination and treatment, and not to choose the drug yourself.