Acute diffuse proliferative glomerulonephritis, also called intracapillary proliferative glomerulonephritis, is a self-limiting disease that requires bed rest, foci of infection, symptomatic supportive therapy, part of the need for glucocorticoids or dialysis. 1. General treatment: in the acute stage, rest should be taken for 2~3 weeks until the disappearance of hematuria, the subsidence of edema and the return of blood pressure to normal. 2. Treatment of infected foci: For active upper respiratory tract or skin infection, antibiotics without nephrotoxicity should be used for 10 to 14 days, such as penicillin and cephalosporin. 3. Symptomatic treatment: Limit water and sodium intake, edema is still obvious, should be appropriate use of diuretics, more commonly used furosemide, hydrochlorothiazide, hypertensive patients need to carry out antihypertensive treatment, more commonly used fosinopril, irbesartan, nifedipine controlled-release tablets and so on. 4. Glucocorticoid therapy and dialysis treatment: if the renal biopsy suggests that there are more crescent formation, the course of the disease is rapid progress, the treatment is similar to crescent nephritis, and can be used to high-dose methylprednisolone shock treatment. For patients with volume overload, cardiac failure, pulmonary stasis, poor diuretic therapy or acute renal failure with indication for dialysis, dialysis should be performed in a timely manner. The disease is a self-limiting disease, but it is recommended that patients consult a hospital in a timely manner, under the guidance of a doctor, the vast majority of patients will be completely cured after active treatment.