Major triplets can be converted to minor triplets. Hepatitis B is a very common infectious disease, after infection with the hepatitis B virus, especially in adolescence, most of the major triplets as the main performance, at this time the virus replication is very active, more infectious, but no immune recognition and immune clearance, this part of the patient does not need special treatment. With age, the body’s immune function will gradually improve, immune clearance will occur, and spontaneous clearance of the virus can occur, followed by the transformation of major triplets into minor triplets. In addition, for some patients with active major triplets, if given aggressive antiviral and other comprehensive treatment, the conversion of major triplets can also occur, with serological conversion of E antigen to minor triplets. The conversion of major triple-positive to minor triple-positive indicates that the degree of hepatitis B virus replication is gradually diminishing and the disease is entering a relatively stable phase.