Some pain in the urethra after urination, it is recommended to go to the hospital for examination, to clarify the cause of the disease and then symptomatic treatment. First, diagnosed with urinary tract infection, it is recommended to take oral anti-infective drugs, such as quinolone antibiotics, commonly used levofloxacin hydrochloride capsules, ciprofloxacin tablets, etc., but also oral cephalosporin antibiotics, commonly used cephalexin capsule or cefuroxime tablets, etc., anti-infective treatment is generally one week a course of treatment, the infection is controlled after the pain can be relieved after urination. Secondly, if the examination confirms the existence of urethral calculi, it is necessary to carry out stone removal or lithotripsy and other treatments under urethroscope, after removing the irritating lesions of stones, the pain after urination can be restored to normal. Thirdly, if there is tumor in urethra, the pain can be accompanied by bleeding, after diagnosis, it is necessary to carry out urethroscopic tumor removal surgery, which requires hospitalization under general anesthesia, and after the removal of the tumor and waiting for the mucous membrane to return to normal, the pain after urination can disappear.