Tadalafil 5 mg can be taken on a regular basis, but for people with renal insufficiency and liver damage, adjustments in dosage and duration of administration are required. If the patient does not have liver or kidney impairment then it can be taken for a long period of time, the drug dosing method is generally divided into on-demand, once a day, and once a day dosage is initially 2.5 mg, and subsequently can be adjusted to 5 mg according to the situation. For patients with renal insufficiency and liver injury, the dosage needs to be adjusted. 1. For patients with severe renal insufficiency who can only take the drug on demand, the maximum recommended dose is 5 mg no more than once every 72 hours, and once-daily administration of tadalafil tablets is not recommended. 2. Tadalafil tablets should be used with caution in patients with mild or severe liver injury, and is not recommended for patients with severe liver injury. All the above medications should be used under the guidance of a doctor, avoid self-medication to avoid adverse consequences.