Doses of aspirin enteric-coated tablets used for antipyretic and analgesic purposes generally cause few adverse reactions. Long-term use of large amounts of drugs (such as the treatment of rheumatic fever), especially when the blood concentration of the drug is > 200μg/ml, is more likely to cause adverse reactions. The higher the blood concentration, the more obvious the adverse reactions. Common adverse reactions include: (1) gastrointestinal reactions: nausea, vomiting, upper abdominal discomfort or pain (caused by the direct stimulation of the gastric mucosa), etc. (incidence 3%-9%), which can disappear after discontinuation of the drug. Long-term or high doses may have gastrointestinal bleeding or ulcers. (2) Central nervous system toxicity: reversible tinnitus and hearing loss, mostly after a certain course of treatment and blood concentration of 200-300g/L. (3) Allergic reactions: appear in 0.2% of patients, manifested as asthma, urticaria, angioneurotic edema or shock. Most of them are susceptible and have respiratory distress rapidly after taking the drug, which can cause death in serious cases, called aspirin asthma. There is a triad of aspirin allergy, asthma and nasal polyps, often associated with genetic and environmental factors. (4) Liver and kidney function damage: related to the size of the dose, especially when the dose is too large blood concentration of 250μg/ml is prone to occur. The damage is reversible and can be recovered after discontinuation of the drug. However, there are reports of renal papillary necrosis. (5) overdose or poisoning manifestations: ① mild: that is, salicylic acid reaction, mostly seen in rheumatic diseases treated with this product, manifested as headache, dizziness, tinnitus, deafness, nausea, vomiting, diarrhea, drowsiness, mental disorders, excessive sweating, deep and rapid breathing, thirst, involuntary movement of hands and feet (mostly in the elderly) and visual impairment; ② severe: may appear hematuria, convulsions, hallucinations, severe mental disorders, respiratory distress and nameless In severe cases, hematuria, convulsions, hallucinations, severe psychiatric disorders, dyspnea and unexplained fever may occur.