Pimples that turn into hard bags are usually cystic nodular acne, which belongs to the fourth grade of severe acne, and can be treated by general treatment, oral medication and topical medication, with no quick elimination. 1. General treatment: Patients are advised to clean their face with warm water and oil-controlling cleansing products, reduce the intake of milk and high-sugar foods, and avoid squeezing. 2. Topical medication: antibiotic medications such as fusidic acid ointment and mupirocin ointment can be used externally. 3. Oral medication: patients can take oral antibiotic drugs, such as doxycycline, minocycline, etc. to improve; can also take oral isotretinoin to regulate the secretion of sebum, follicle keratinization and so on. For acne into hard bags of patients, it is recommended to timely to the regular hospital for examination, under the guidance of a professional doctor to standardize the treatment, the above drugs need to be used in strict compliance with the doctor’s instructions.