Allergic manifestations of iodine contrast can appear as erythematous, well-defined erythema at the site of static spot or intramuscular contrast injection, which can be covered by small papules, corn to rice grain size, and accompanied by some pruritus. For treatment measures, oral levocetirizine hydrochloride granules and epinastine hydrochloride capsules can be taken, and topical hydrocortisone butyrate ointment mixed with zinc oxide boric acid ointment can be applied topically. Fusidic acid ointment and compound polymyxin B ointment can be applied to the site of the pinhole. If the rash persists and does not subside and the redness is more intense, anti-allergy treatment can also be administered by quietly ordering compound glycyrrhetinic acid monoamine injection and compound glycyrrhetinic acid glycoside injection.