Domestic tenofovir ester treatment effect is relatively good. Tenofovir is an oral drug for the treatment of hepatitis B. It belongs to a new type of nucleotide inhibitor, with the help of an optimized structure, thus having a higher cell membrane penetration rate, easier to enter the hepatocyte, to achieve the purpose of liver-targeted therapy, which helps to improve the plasma stability of this drug, so it is a kind of drug that can be used for long-term treatment with a more stable effect. The more common adverse reactions to tenofovir include generalized weakness, dyspnea, dizziness, headache, and diarrhea, and it is contraindicated in people who are allergic to any component of tenofovir. The use of tenofovir has certain risks, patients need to get the guidance of a specialist, not unauthorized use.