Mild skin ulcers caused by tincture of colchicine can usually heal spontaneously after stopping the drug. Individual patients with severe local reactions, should immediately stop the drug to seek medical treatment. Tincture of disulfiram is mainly used to treat male and female genitalia and perianal parts of the warts, the drug has a certain degree of corrosiveness, the use of tincture of disulfiram can be coated with varying degrees of burning or tingling sensation and redness, edema, and vesiculation, for the common local reaction, suspension of the drug can generally be self-healing. Local serious ulcers, edema, severe pain, can not be self-healing, should immediately stop using the drug, timely to the hospital. Because of the high irritation of the drug, try to avoid the liquid contact with the skin and mucous membranes. It is not recommended to be used in the oral cavity, if accidentally taken by mistake can cause serious adverse reactions. The medication should be used in strict compliance with the doctor’s instructions, avoiding arbitrary use by oneself.