Whether the gastric sinus lesion is serious or not should be judged according to the specific situation and type of the lesion. Generally, there are atrophic gastritis, gastric polyp and gastric cancer, etc. Atrophic gastritis and gastric polyp are generally not serious, while gastric cancer is more serious. 1. Atrophic gastritis: it belongs to a kind of precancerous lesion, which is relatively not very serious and can get better prognosis through treatment. For example, if the patient is infected with Helicobacter pylori, he can take clarithromycin and amoxicillin under the guidance of doctor and combine with Omeprazole and other proton pump inhibitors, and bismuth such as bismuth potassium citrate to give the treatment. 2. Gastric polyps: there are more types of gastric polyps, including hyperplastic polyps, fundic gland polyps, and adenomatous polyps, etc. Many patients have hyperplastic polyps, which are mostly benign and not very serious, and they can be treated by surgery, but if they are adenomatous polyps, they will be more serious and have cancerous possibility. 3. Gastric cancer: malignant tumor at the gastric sinus, which is more serious, patients need to take pathology under endoscopy to identify the nature and stage of the tumor, and then give symptomatic treatment, usually radical surgical resection is given. For advanced patients, who cannot be operated, chemotherapy treatment can be considered, and commonly used chemotherapy drugs are capecitabine, oxaliplatin and so on. Gastric sinus lesions recommend that patients go to the hospital in a timely manner, to clarify the nature of the lesion, and then follow the doctor’s instructions to give effective treatment, so as to avoid the development of the disease, making it more difficult to treat.