Pantoprazole sodium and omeprazole belong to the same proton pump inhibitor, there is no which one is better, it is recommended to follow the doctor’s instructions to take medication. Pantoprazole sodium is used in the treatment of active peptic ulcer, reflux esophagitis, gastrinoma and other diseases. Adverse reactions such as dizziness, headache, drowsiness, abdominal pain, diarrhea, constipation, hypomagnesemia may occur during administration. It is contraindicated in people who are allergic to the product, breastfeeding and women in the third trimester of pregnancy. There are interactions with ribavirin, digoxin, clopidogrel and other drugs. Omeprazole is clinically used in the treatment of peptic ulcer, gastroesophageal reflux disease, gastrinoma and other diseases. Common adverse reactions are headache, abdominal pain, diarrhea, constipation, atrophic gastritis, hypomagnesemia, leukopenia and so on. It is contraindicated in people who are allergic to the product. Omeprazole has drug interactions with nelfinavir, rilpivirine, clopidogrel, and cilostazol. The treatment plan of the drug is an individualized treatment plan made by the doctor after weighing the pros and cons, and the patient does not need to have too much psychological burden. It is recommended to take the medication as prescribed by the doctor to avoid adverse effects.