Pressure chest pain while sleeping is generally due to long-term late nights, or poor sleep posture, especially lying down position, sleeping is easy to cause long-term pressure on the muscle soft tissues of the anterior chest wall, under the action of gravity, resulting in intercostal muscle flesh and nerves irritating pain, and non-specific infections, such as intercostal neuralgia or intercostal neuritis, etc., in a poor sleep posture or extrusion is easy to stimulate the nerve endings , leading to pain in the chest. Clinically, there are also some geriatric underlying diseases, such as coronary heart disease, angina pectoris or insufficient blood supply to the heart, resulting in coronary syndrome or pleurisy, which can cause significant chest pain, so the phenomenon of sleeping and squeezing chest pain, we should go to the regular hospital for a detailed examination, to find the exact cause of the disease for thorough treatment.