The most serious diseases of the eye include retinal detachment, intraorbital tumors compressing the optic nerve, wet age-related macular degeneration, and fungal corneal ulcers. 1. Retinal detachment: the effect of surgical treatment is very poor, and even this disease may lead to atrophy of the eyeball and blindness. 2. Orbital tumor compressing the optic nerve: it may directly cause blindness. 3. Wet age-related macular degeneration: the prognosis of this disease is very poor, and the treatment effect is very bad. 4. Fungal corneal ulcer: this kind of ulcer is very difficult to be cured, and in serious cases, it can lead to corneal perforation, or even need to remove the eyeball. Eye discomfort symptoms, especially the emergence of more serious symptoms should go to the regular hospital ophthalmology consultation, early detection, early diagnosis, early treatment, so as not to cause serious consequences.