Xie Anzhi is the trade name, valsartan amlodipine belongs to the compound preparation, which has good antihypertensive effect. Valsartan amlodipine includes two ingredients, valsartan and amlodipine. The main effect of valsartan is to have an antagonistic effect on the angiotensin II receptor in the body, and amlodipine belongs to the calcium antagonist, the two drugs have the same mechanism of action, so they have a synergistic antihypertensive effect, and some of the adverse effects of the drugs can be offset. Valsartan and amlodipine belong to a better combination, the two drugs at the same time to take the antihypertensive effect will be significantly enhanced, but the drug should pay attention to avoid the blood pressure level is too low, to strengthen the monitoring of blood pressure, the elderly patients can start taking a small dose. Adverse effects of valsartan amlodipine include flushing, palpitations, constipation, flu-like symptoms, dizziness, elevated blood potassium, etc. It is contraindicated for patients with allergy to drug components, hypotension, hyperkalemia, and severe renal impairment.