Elderly calf skin white spots may be caused by vitiligo, senile leukoplakia, fungal infections, etc. According to the cause of the disease, topical fluticasone propionate cream, tacrolimus ointment, sunscreen, terbinafine cream and so on are needed for relief. 1. Vitiligo: is due to the destruction of melanocytes lead to skin white spots, manifested as pigmentation loss spots, often milky white, but also light pink, can follow the doctor’s instructions to use fluticasone propionate cream, tacrolimus ointment and other drugs to ease. 2. Geriatric leukoplakia: it is a degenerative phenomenon of senile skin, the cause of which is not yet clear, and it is considered to be a physiological phenomenon of skin aging. It can lead to the appearance of round or oval white spots with the size of a needle tip to a green bean on the local skin of the patient. Generally, there is no need for special treatment, pay attention to good skin sunscreen, sunscreen can be applied when you go out, if necessary, fractional laser treatment. 3. Fungal infections: fungal infections can also lead to skin pigmentation loss white spots, can be treated with topical antifungal drugs, such as ketoconazole ointment, terbinafine cream, etc.; if necessary, oral antifungal drugs, such as itraconazole, etc. for relief. Older calf skin white spots may have other reasons, it is recommended to go to the hospital to clarify the cause of the disease, the above drugs need to be used in accordance with medical advice.