Aldosterone increase, cortisol increase and catecholamine increase will appear in the middle stage of adrenal cancer. 1. Aldosterone increase: mainly manifested as hypertension and hypokalemia. In hypertension, increased diastolic blood pressure is the main manifestation. Because most patients have persistent hypokalemia, it manifests as muscle weakness or even periodic paralysis. Because of the reduced concentration function of the kidney, symptoms such as irritable thirst, polydipsia and polyuria will appear. 2. Cortisol increase manifestation: there will be symptoms such as centripetal obesity, full moon face, buffalo back, visible acne, irregular menstruation and so on. 3. Catecholamine increase: there are persistent hypertension, paroxysmal hypertension, manifested by severe headache, pallor, nausea, vomiting and other symptoms. If you have any of the above symptoms, it is recommended that you seek timely medical treatment to minimize the adverse effects of the disease.