If you have a headache in the middle of the night and cannot sleep, you should try to calm down and massage the Hegu point and the solar plexus for 15-20 minutes, with the Hegu point at the tiger’s mouth of the thumb and index finger and the solar plexus in the recesses on both sides of the eyes. If the headache is relieved but you still cannot sleep, consider taking sleeping pills in moderation to deepen your sleep in strict accordance with the instructions. If the headache is still not relieved, you can measure your blood pressure at home in a soothed state. If the headache is caused by elevated blood pressure, you can take the appropriate amount of antihypertensive medication according to your past medication history, and then go to the hospital the next day to get the medication under the diagnosis of your doctor. If you have cluster headache, which can also cause midnight headache, generally the headache is more intense and can be accompanied by nausea and vomiting, causing sleeplessness in the middle of the night, you can apply zolmitriptan, sumatriptan, etc. for symptomatic pain relief treatment. In addition, if the headache is accompanied by symptoms such as aphasia, hemiparesis or even impaired consciousness, it may be caused by intracranial organic lesions, such as cranial tumors, subarachnoid hemorrhage and cerebral hemorrhage, which require prompt examination of cranial MRI and cranial CT in the emergency room, and then the doctor will decide the follow-up treatment.