Itchy blisters on the soles of the feet may be caused by tinea pedis, herpes sweating and palmoplantar pustulosis, etc. Depending on the cause, you can choose antifungal drugs and glucocorticoid drugs to treat it, including econazole, trimethoprim and hydrocortisone. 1. Tinea pedis: Tinea pedis may cause blisters on the soles of the feet that are a bit itchy. Antifungal drugs can help treat tinea pedis, and it is recommended that patients apply bifonazole, econazole, and other drugs, which can inhibit the bacteria, and then relieve the itching. 2. Sweat herpes: If sweat herpes causes blisters on the soles of the feet a little itchy, sweat herpes patients should use topical tretinoin, mometasone furoate glucocorticosteroid ointment, which can relieve itching and help reduce inflammation. 3. palmoplantar pustulosis: if palmoplantar pustulosis triggers blisters on the soles of the feet a little itchy, patients can apply glucocorticoid drugs for treatment, including hydrocortisone, dexamethasone, etc., which can play a role in relieving itching and anti-inflammatory effects. The causes of blisters on the soles of the feet are more, it is recommended that patients go to the regular hospital, with the doctor for standardized treatment.