Anti-inflammatory drugs generally refer to antibiotics, and there is no such thing as the best antibiotic for a sore throat from a cold. Sore throat from a cold can be treated empirically with appropriate antibiotics if there is a basis for secondary bacterial infection. Cold sore throat is mostly related to edema of the throat caused by viral infection or a state of neural hypersensitivity due to inflammatory mediators, and antibiotic treatment is generally not required. As there is no specific antiviral drug, except for influenza, antiviral treatment is also not necessary, and more bed treatment, drinking more water and other general measures to treat, such as more serious symptoms, can be given the appropriate symptomatic treatment. If there is evidence of bacterial infection such as elevated white blood cells, pharyngeal pus moss, coughing up yellow sputum and running yellow nose, oral penicillins such as amoxicillin, first-generation cephalosporins such as cephradine, and macrolides such as azithromycin can be selected according to local epidemiologic history and experience. Rarely, sensitive antibiotics need to be selected based on the causative organism. Sore throat can also be caused by other diseases, if the symptoms do not improve or aggravate, it is recommended to consult a doctor in a timely manner, under the guidance of the doctor, follow the doctor’s instructions to standardize the use of medication.