Diabetes is the most common metabolic disease with a global epidemic trend. Like diabetes, hyperuricemia is a metabolic disease, and the incidence of hyperuricemia is much higher in diabetic patients than in the general population. Hyperuricemia can lead to serious cardiovascular and cerebrovascular hazards, especially in patients with diabetes mellitus combined with hyperuricemia. Therefore, patients with diabetes mellitus combined with hyperuricemia need to pay attention to the control of the invisible fourth high – hyperuricemia.