Vaginal swelling and tingling can occur during radiotherapy for rectal cancer, which is a skin stress reaction within the radiation range. Rectal cancer is a common malignant tumor of the intestinal tract, which can be caused by heredity, gene mutation and other factors. One of the main treatments after diagnosis of the disease is radiotherapy, which can use the energy released by high-energy rays to achieve the purpose of killing tumor cells. Due to anatomical factors, radiotherapy for rectal cancer can lead to emergency reactions in the skin within the radiotherapy area. For example, the symptoms of swelling and itching in the vaginal area can be accompanied by itching, deepening of pigmentation, follicular erythema and other manifestations. In addition, the genitourinary system reaction can also occur, specifically manifested as urinary discomfort, urinary frequency, urinary pain, urinary urgency and other symptoms. It is recommended that patients should consult a doctor in time after the occurrence of the above symptoms, and be treated by the doctor according to the situation.