Waking up with joint pain may be non-pathological factors, such as strenuous exercise, improper sleeping posture, caused by cold, but also may be pathological factors, such as rheumatoid arthritis, ankylosing spondylitis, gouty arthritis and other causes, further examination is required to confirm the diagnosis, and then actively treat the cause after clarification. Non-pathological factors: 1, strenuous exercise: for example, long-term inactivity, after strenuous exercise can lead to overexertion, muscle anaerobic metabolism generates lactic acid, lactic acid accumulation in the joints and muscle tissue, causing joint pain when waking up from sleep, this situation can be gradually relieved through rest and hot compresses, generally without special treatment; 2, improper sleeping posture: for example, prolonged pressure on the joints during sleep, can lead to joint Poor blood circulation, local ischemia and hypoxia can lead to joint pain after waking up. Treatment can be local hot compresses or appropriate joint activities, if necessary, under the guidance of a doctor can be used externally non-steroidal drugs, such as flurbiprofen gel paste, diclofenac diethylamine emulsion; 3, cold: night sleep joint cold, can cause local aseptic inflammation, inflammatory stimulation can also cause joint pain after waking. Treatment can be local heat or infrared physiotherapy, generally do not need special medication, usually pay attention to keep warm. Second, pathological factors: 1, rheumatoid arthritis: the cause is mostly autoimmune factors and genetic factors, mainly rheumatoid factors acting at the joints, causing morning joint stiffness, soreness, thus manifesting as waking joint pain, pain with wandering and joint swelling, rheumatoid arthritis more involved in the small joints of the hands and feet, and symmetrical joint pain, swelling. The treatment can be under the guidance of a doctor using methotrexate tablets, pain relief available non-steroidal anti-inflammatory drugs, such as diclofenac sodium extended-release tablets or ibuprofen extended-release tablets; 2, ankylosing spondylitis: the cause of the same genetic and autoimmune factors, the early stage is mainly sacroiliac joint pain, middle and late stage lesions involving the spine, by night rest can lead to increased joint inflammation, manifested as morning joint stiffness, waking up joint pain. Treatment is mainly to control inflammation, reduce or alleviate symptoms, can be used under the guidance of a doctor thalidomide tablets, lorazepam enteric soluble tablets, pain relief can be used loxoprofen sodium tablets; 3, gouty arthritis: patients with previous hyperuricemia, in the previous night if you eat too much purine content of food, such as seafood, beer, etc., can cause gouty arthritis, resulting in sleep joint pain, and joint redness and swelling is obvious, and The skin temperature increases. After the symptoms are controlled, febuxostat can be used to regulate uric acid metabolism and a low purine diet.