Painful swollen lymph nodes require medication, and it is recommended to take antibiotic and anti-inflammatory drugs under the guidance of a doctor in appropriate amounts for treatment. Antibiotics: swollen and painful lymph nodes, it is recommended to take antibiotic drugs under the guidance of a doctor, usually including cefradine, ciprofloxacin, levofloxacin and other drugs. It can make the surface redness and swelling subside, the lymph nodes shrink and the pain reduce. If the swelling of lymph nodes is relieved, you can consider stopping the drug, if the lymph nodes have symptoms of swelling or pus, you need to go to the hospital in time. Anti-inflammatory and analgesic drugs: lymph nodes are swollen and painful, it is recommended to take anti-inflammatory and analgesic drugs, such as celecoxib capsules, under the guidance of a doctor. It can relieve the pain. If the patient has symptoms of swollen and painful lymph nodes, it is recommended to go to the hospital and use drugs under the guidance of the doctor.