Irbesartan and nifedipine controlled-release tablets can be taken together, and need to be coadministered under the guidance of a doctor. Irbesartan is an angiotensin-II receptor antagonist with blood pressure-lowering effect, which has no effect on kidney and blood sugar. It is used for the treatment of primary hypertension and type 2 diabetic nephropathy combined with hypertension. Adverse reactions include postural hypotension, fatigue, dizziness, vomiting and nausea. The drug is contraindicated in pregnancy (4 to 9 months), breastfeeding, and hypersensitivity to the product. Nifedipine controlled-release tablets are a calcium antagonist that dilates coronary arteries, reduces peripheral resistance and blood pressure. Adverse reactions can be seen as edema, headache, constipation, dizziness, palpitations, hypotension and so on. The drug is contraindicated in people who are allergic to the product, cardiogenic shock, within 20 weeks of pregnancy, and lactating women. Nifedipine controlled-release tablets instructions pointed out that the pharmacokinetics of this product and irbesartan with the use of no effect, there is no drug interaction, therefore, when the blood pressure is high, an antihypertensive drug treatment effect is not good, you can follow the doctor’s instructions for joint use of drugs.