Persistent insomnia, as a kind of insomnia, is one of the common clinical diseases, which is manifested by long-term inability to sleep normally, often sleepless nights, poor rest and poor recovery of the body, often making people distracted, tired and weak, lack of energy and emotional disorders, which seriously affects people’s life and work. As one third of a person’s life is in sleep, the quality of sleep is directly related to the health of the human body, sleep as a necessary process of life, is an important part of the body to demobilize, consolidate and integrate memory, is an important and indispensable part of health, the existence of persistent insomnia, can seriously affect the health of people. There are many causes of intractable insomnia, which is one of the reasons for the difficulty of treatment. Although there are many clinical methods for the treatment of intractable insomnia, often emphasis is placed on a single method of treatment, and the treatment is difficult to be effective due to the loss of one side. Therefore, we should analyze the causes of stubborn insomnia, understand various treatment methods, absorb the essence, adopt comprehensive therapy to treat stubborn insomnia, rationalize the use of drugs, reduce the use of drugs, and adopt a variety of methods to treat stubborn insomnia in order to achieve the desired effect, improve sleep, restore normal life, and avoid the damage of insomnia to the body.