Snakeskin-like skin on the legs is generally caused by ichthyosis, there is no cure, relief treatment includes general treatment, medication to help remove. 1. General treatment: ichthyosis can lead to a decline in the skin’s defense function, so you need to pay attention to skin care in daily life, often apply vitamin E milk and other moisturizing skin care products. Frequent baths or long showers can soften the skin, the water should not be too hot when bathing, and the scrubbing should not be too hard to remove the surface scales. 2. Medication: It is necessary to choose appropriate medication under the guidance of a doctor. Commonly used medications include topical medications and oral medications. Topical drugs include urea cream, petroleum jelly, 10% cholesterol cream, tazarotene and so on. Oral medications include retinoids such as Avianol. When you develop snakeskin-like skin on your legs, you should go to the hospital immediately and follow your doctor’s instructions for treatment.