The specific hazards of applying antibiotics to babies are as follows: a. Antibiotics can damage the liver and kidney function of babies, and the damage can be worse when applied in large doses or irregularly, such as macrolide antibiotics have liver damage, and can also cause side effects in the gastrointestinal tract when applied in large doses, which can cause severe nausea, vomiting or diarrhea and other situations. Second, it is easy to cause dysbiosis, which can lead to gastrointestinal dysfunction, diarrhea or constipation and other digestive problems in babies. Third, ototoxicity, nephrotoxicity, the need to strictly comply with the pediatric drug guidelines. Fourth, long-term application of antibiotics when the baby’s flora dysbiosis, producing drug resistance. So the baby should have clear indications for the use of antibiotics in the application, according to the disease to control the amount of use as well as the time of use.