The antihypertensive drugs currently recommended for use in clinical practice are basically harmless to the liver and kidneys of the general population, but certain drugs may have adverse effects on patients with poor hepatic and renal function and need to be taken with caution. Antihypertensive drugs mainly include calcium antagonists, such as nifedipine and felodipine, angiotensin-converting enzyme inhibitors and angiotensin receptor inhibitors, such as captopril and cloxartan, and beta-blockers, such as propranolol. These drugs have essentially no effect on the function of the liver and kidneys in the general population. However, it should be noted that angiotensin-converting enzyme inhibitors and angiotensin receptor antagonists are contraindicated in patients with severe hepatic and renal insufficiency, or they may aggravate hepatic and renal impairment. Therefore, the use of antihypertensive drugs should be carried out under the guidance of a doctor, and if there are contraindications to the drug, it should be replaced with other drugs.