Current research suggests that there is no consensus on the effect of smoking on blood uric acid, and further research is still needed. On the one hand, smoking increases the activity of xanthine oxidase, which promotes the production of uric acid, and also increases the reabsorption of uric acid. Smoking also stimulates the body’s oxidative stress response, which leads to a decrease in the excretion of uric acid from the kidneys or intestines, thus leading to an increase in uric acid levels. On the other hand, some studies have suggested that smoking is beneficial in lowering uric acid levels, due to the compensatory increase in uric acid consumption that occurs after smoking, which leads to lower uric acid levels. However, it is not recommended to lower uric acid levels by smoking. Smoking itself has many harmful effects, so all things considered, it is better to quit smoking and prevent the problem before it occurs. It is recommended that patients with uric acid abnormalities go to the hospital in a timely manner and follow the doctor’s instructions for standardized treatment to avoid delays.