Insulin resistance refers to the insufficient effect of insulin to perform its normal biological role, which is manifested by the impaired utilization of glucose by peripheral tissues, especially muscle and adipose tissues, and early on, pancreatic β-cells can compensate for the insufficient effect by increasing insulin secretion, but over time, the function of pancreatic β-cells will gradually weaken, leading to abnormal glucose tolerance and diabetes. Among the risk factors of cardiovascular diseases, insulin resistance is at the core, or insulin resistance is a common risk factor for many diseases, especially diabetes and cardiovascular diseases, and is the common ground for the development of many metabolic-related diseases. Epidemiological data show that insulin resistance can exist years before the onset of diabetes and cardiovascular diseases, and is often accompanied by obesity, aging, hypertension, and hyperlipidemia. The combination of insulin resistance, central obesity, reduced glucose tolerance or diabetes mellitus, hypertension, and disorders of lipid metabolism is currently referred to collectively as the metabolic syndrome or insulin resistance syndrome. Therefore, insulin resistance is an important cause that contributes to the development and occurrence of diabetes, hypertension, hyperlipidemia and other diseases. 1.Insulin resistance and hypertension In the early stage of insulin resistance, hyperinsulinemia accelerates the heart rate by affecting sympathetic nerve activity, which promotes the proliferation of small arteries, making them more sensitive to the response of blood pressure-raising substances, and over time, hypertension is formed. 2, insulin resistance and diabetes At the advanced stage of insulin resistance, the pancreatic islets fail and cannot secrete the normal amount of insulin, which makes the blood sugar uncontrolled, and then diabetes appears. After the emergence of diabetes, the fat metabolism disorder is aggravated and blood pressure is further increased. Therefore, hypertension and diabetes are a pair of brothers in distress that are interrelated and affect each other, and they cannot be diagnosed and treated in isolation and separately from each other. Hypertension and diabetes fuel each other, making people’s chances of myocardial infarction or cerebral infarction increase exponentially. 3, insulin resistance and obesity type 2 diabetes patients are mostly obese people is a well-known fact. This is because the metabolic disorder of type 2 diabetes patients will make the degree of insulin resistance increased accordingly. Generally speaking, obese people with high blood lipid levels in the body, and mostly abdominal obesity (that is, fat accumulation to the abdomen), which will promote insulin resistance, and insulin resistance in turn will aggravate the metabolic disorders, which forms a vicious circle. 4, insulin resistance and hyperlipidemia When insulin resistance exists, the normal physiological activities of the liver are affected, so that the synthesis of free fatty acids and triglycerides increases. Free fatty acids and triglycerides will reduce insulin sensitivity, thus it is believed that insulin resistance is closely related to disorders of lipid metabolism. 5, insulin resistance and coronary heart disease Research shows that insulin resistance is one of the risk factors of coronary heart disease. The pathogenesis of coronary heart disease confirms that insulin resistance is related to vascular damage and disorders of lipid metabolism, which greatly increases the chance of coronary atherosclerosis, and thus the incidence of coronary heart disease in patients with insulin resistance increases significantly.