If minimally invasive surgery for ankylosing spondylitis is still painful, symptoms can usually be improved by general treatment and medication. Ankylosing spondylitis is a common clinical type of spondyloarthritis, with predominant involvement of the mid-axis joints, which may be accompanied by extra-articular manifestations, and in severe cases, spinal ankylosis and deformity may occur. Attachment point disease (inflammation) is the basic lesion of this disease. The sacroiliac joint is the earliest part of the disease, and the pathological manifestations are synovitis, cartilage degeneration and destruction, subchondral bone plate destruction and inflammatory cell infiltration. If the minimally invasive surgery for ankylosing spondylitis is still painful, the symptoms can usually be improved by general treatment and medication. 1. General treatment: In daily life, patients with ankylosing spondylitis need to exercise moderately, such as practicing tai chi, jogging, etc., which can appropriately increase the lung capacity and muscle strength; when sleeping, they need to try to choose a soft and hard bed. Also need to pay attention to diet, do not pick food, partiality, overeating, to maintain balanced nutrition. 2. Drug therapy: patients can take non-steroidal anti-inflammatory drugs under the guidance of doctors, such as diclofenac sodium, celecoxib and so on to anti-inflammatory, analgesic, can relieve the pain of the low back; can also follow the doctor’s instructions to take immunosuppressant such as lauzasulphonyl pyridine and methotrexate and so on, in order to slow down the process of the development of the disease. Ankylosing spondylitis patients, it is recommended to go to a regular hospital, under the guidance of the doctor standardized treatment.