The treatment of severe mitral valve insufficiency mainly consists of internal medicine and surgery. 1.Internal medicine treatment In acute severe mitral valve insufficiency, patients often have symptoms of heart failure and even shock. Arterial dilators such as prostaglandin and nifedipine can be used as prescribed by the doctor to lower the resistance of blood flow in the body circulation, and if hypotension has already occurred, intra-aortic balloon counterpulsation is feasible. Patients may also require cardiotonic therapy such as cediran. Chronic severe mitral valve insufficiency requires early use of drugs such as Benadryl to reduce left ventricular volume as prescribed by the doctor. 2. Surgery: Surgery is the fundamental treatment for severe mitral valve insufficiency. Acute severe mitral valve insufficiency should be treated with urgent or elective mitral valve repair or replacement, while chronic severe mitral valve insufficiency should be treated with surgery as soon as possible. Therefore, patients with severe mitral valve insufficiency should seek timely consultation and early treatment to avoid delaying the condition and affecting the prognosis.